Mycobacterium leprae in bone marrow
نویسندگان
چکیده
The case of a 54-year-old man, who was referred to evaluate a consumptive syndrome with anemia and fever of unknown origin, is reported. A physical examination revealed madarosis, nodular lesions on the ears, nasal soft tissue collapse, subcutaneous nodules on arms and generalized lymphadenopathy. Laboratory tests showed anemia (Hb 8.8 g/dL, mean corpuscular volume 82.4 fL, mean corpuscular hemoglobin 24.5pg), normal reticulocyte count (0.5%), thrombocytosis (482×109/L), normal serum ferritin (268ng/mL) and elevated C-reactive protein (124mg/L). Serologies (viral hepatitis and human immunodeficiency virus) were non-reagent. Lepromatous leprosy was confirmed by staining for acidfast bacilli using samples from the ear and subcutaneous nodules and bone marrow smears. Bone marrow was hypercellular with myeloid hyperplasia (myeloid–erythroid ratio 7:1) but without dysplasia. Mycobacterium leprae was detected lying free and in foamy histiocytes named Virchow cells (Figures 1 and 2).1,2 A multidrug therapeutic regimen (clofazimine, dapsone, rifampicin) was established with progressive improvement.
منابع مشابه
Studies in the viability of Mycobacterium leprae in human liver and bone marrow using thymectomized mouse foot pad technic.
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عنوان ژورنال:
دوره 36 شماره
صفحات -
تاریخ انتشار 2014